What is the viscosity of HPMC K100M?

HPMC K100M is a specification of Hydroxypropyl Methylcellulose, which is mainly used as pharmaceutical excipients and thickeners. There are many types of HPMC, and HPMC of different specifications have different performance parameters, such as viscosity, degree of substitution, etc. Among them, K100M is named by its viscosity grade and is a high-viscosity product.

HPMC K100M Viscosity

The viscosity of HPMC K100M is hinted at in its name. Specifically, the "100M" in K100M means that its solution viscosity range under certain conditions is 100,000 millipascal seconds (mPa·s), that is, 100,000 centipoise (cP).

The solution viscosity of HPMC depends on several major factors:

Concentration: The solution viscosity of HPMC has a great relationship with its dissolved concentration. Generally, the higher the concentration, the greater the viscosity.

Solvent: The viscosity of HPMC is usually measured in water, but it can also be measured in other solvent systems, such as a mixed solvent of ethanol and water.

Temperature: Temperature has a significant impact on the viscosity of HPMC solution. Generally, an increase in temperature will cause a decrease in solution viscosity.

Measurement conditions: The viscosity is usually measured using a spindle viscometer at a certain rotation speed, so the specific conditions will affect the results.

Applications of HPMC K100M

Due to its high viscosity, HPMC K100M has a wide range of applications in various industrial and pharmaceutical fields, especially in the following aspects:

Pharmaceutical preparations: In pharmaceutical preparations, HPMC K100M is used as a sustained-release material and is widely used in the production of sustained-release coatings for tablets and sustained-release matrix tablets. This is due to its high viscosity and good adhesion properties, which allow the drug to be released slowly in the digestive tract.

Food industry: In the food industry, HPMC is used as a thickener, emulsifier and stabilizer to improve the texture and stability of products. For example, it can be added to dairy products, beverages and condiments to improve taste and consistency.

Coatings and Building Materials: HPMC K100M is widely used in the construction industry as a thickener and water retaining agent in coatings, adhesives and mortars. In these applications, HPMC improves the material's handling properties and reduces moisture loss, thereby improving construction quality.

Viscosity measurement conditions

The viscosity of HPMC K100M is usually measured under 2% solution conditions, that is, HPMC K100M is dissolved in water to prepare a 2% solution at a temperature of around 20°C, and then measured using a viscometer. The viscosity at this point should be approximately 100,000 mPa·s. At other concentrations, the viscosity will vary. For example, at low concentrations (e.g., 1% or less), the viscosity decreases significantly.

HPMC K100M produced by different manufacturers may have differences in specific production processes and details. Therefore, in specific application scenarios, users may need to refer to the technical indicators and test data provided by the manufacturer.

Relationship between viscosity and performance

Viscosity is one of the most important indicators to measure HPMC K100M, because it is directly related to the application effect of the product. In pharmaceutical formulations, higher viscosity contributes to the sustained release and film-forming properties of the drug. In industrial applications such as food and construction, high viscosity also means that the product can provide better adhesion and stability.

However, it should be noted that too high a viscosity may also have adverse effects. For example, in the pharmaceutical field, too high a viscosity may increase the difficulty of mixing during production, resulting in longer disintegration time of tablets; in food applications, it may affect the taste of the final product. Therefore, in practical applications, the choice of viscosity needs to be weighed and adjusted according to specific needs.

HPMC K100M has a viscosity of approximately 100,000 mPa·s, and its high viscosity properties make it widely used in various fields such as pharmaceuticals, food and construction. When using HPMC K100M, the appropriate concentration and operating conditions should be selected according to the application scenario to obtain the best performance. At the same time, the conditions for viscosity measurement, such as solution concentration, temperature and solvent selection, will also have a significant impact on the final result. Therefore, in actual use, detailed technical data and recommendations provided by the manufacturer should be consulted according to specific operating conditions.