L-HPC LH21

Specification of L-HPC LH21

Application of L-HPC LH21

KimaCell^® L-HPC LH21 Low-Substituted Hydroxypropyl Cellulose is widely used in pharmaceutical excipient.

As a disintegrant for solid preparations such as tablets

The surface of low-substituted hydroxypropyl cellulose crystalline particles is uneven, with obvious weathered rock-like structure. This rough surface structure not only makes it have a larger surface area, but also when it is compressed into a tablet together with drugs and other excipients, numerous pores and capillaries are formed in the tablet core, so that the tablet core can increase the moisture absorption rate and Water absorption increases swelling. Using L-HPC as an excipient can make the tablet rapidly disintegrate into a uniform powder, and significantly improve the disintegration, dissolution and bioavailability of the tablet. L-HPC has become one of the most important excipients for immediate-release solid preparations due to its strong hydrophilicity, hygroscopicity, expansibility, short hysteresis time for water absorption, fast water absorption speed, and fast water absorption saturation. It is an ideal disintegrant for orally disintegrating tablets. Paracetamol orally disintegrating tablets were prepared with L-HPC as disintegrant, and the tablets disintegrated rapidly within 20s. L-HPC is used as a disintegrant for tablets, and its general dosage is 2% to 10%, mostly 5%.

As a binder for preparations such as tablets and granules

The rough structure of L-HPC also makes it have a greater mosaic effect with drugs and particles, which increases the degree of cohesion, and has good compression molding performance. After being pressed into tablets, it shows more hardness and gloss, thus improving the The quality of the tablet's appearance. Especially for tablets that are not easy to form, loose or easy to uncover, adding L-HPC can improve the effect. The ciprofloxacin hydrochloride tablet has poor compressibility, easy to split and sticky, and it is easy to form after adding L-HPC, with suitable hardness, beautiful appearance, and the dissolution rate meets the quality standard requirements. After adding L-HPC into the dispersible tablet, its appearance, friability, dispersion uniformity and other aspects are greatly improved and improved. After the starch in the original prescription was replaced by L-HPC, the hardness of the azithromycin dispersible tablet was increased, the friability was improved, and the problems of missing corners and rotten edges of the original tablet were solved. L-HPC is used as a binder for tablets, and the general dosage is 5% to 20%; while H-HPC is used as a binder for tablets, granules, etc., and the general dosage is 1% to 5% of the preparation.