HPMC K4M

Specification of HPMC K4M Properties

HPMC K4M Viscosity and Molecular Weight

The apparent viscosity of HPMC K4M solutions can be influenced by factors such as concentration, temperature, and shear rate. As a medium-molecular weight hydroxypropyl methylcellulose (HPMC) thickener, HPMC K4M has a viscosity range of 3200.0-4800.0 cps. With a typical molecular weight of approximately 500 kDa (kilodaltons), it provides excellent performance in formulations that demand consistent texture and stability.

Benefits of HPMC K4M 

Exceptional Biocompatibility

• Water Solubility and Non-Ionic Nature: HPMC K4M is readily soluble in water and carries no ionic charge, minimizing interactions with drug molecules and ensuring optimal drug stability and bioavailability.

• Broad pH Stability: Its stable performance across a wide pH range (2-13) makes it suitable for a variety of pharmaceutical formulations, regardless of the drug's pH sensitivity.

Unique Rheological Properties

• Reversible Thermal Gelation: The ability of HPMC K4M to form gels upon heating and return to a liquid state upon cooling is a key feature for controlled release formulations. By carefully adjusting the temperature, precise control over drug release rates can be achieved.

• Excellent Binding: Its strong binding properties enhance tablet hardness and disintegration time, improving the overall stability of the dosage form.

• Film-Forming Capabilities: HPMC K4M forms robust, water-soluble films that can be used for coating, microencapsulation, and other processes to enhance drug stability and improve taste.

Advantages of HPMC K4M in Pharmaceutical Formulation

• Enhanced Drug Stability: HPMC K4M protects drugs from degradation by factors such as oxidation and hydrolysis.

• Improved Drug Release Characteristics: By manipulating the concentration and processing conditions of HPMC K4M, precise control over drug release rates can be achieved.

• Improved Physical Stability: HPMC K4M enhances the hardness, disintegration time, and flow properties of dosage forms.

• Enhanced Patient Compliance: By improving the taste and physical form of the dosage, HPMC K4M can enhance patient adherence to therapy.

HPMC K4M Uses

KimaCell^® HPMC K4M is currently one of the largest pharmaceutical excipients at home and abroad. Because of its molecular weight and viscosity, HPMC can be used as: binder, disintegrant, slow and controlled release agent, coating film-forming agent, etc. agent etc.

The wholesale HPMC K4M used as the adhesive is of low viscosity specification, and the HPMC solution with a concentration of 2-5% is commonly used as the adhesive, which can make the disintegration rapid and the stripping speed up. Different concentrations have different viscosities, which depends on the nature of the material to be selected through experiments!

Why Choose Kima Chemical's HPMC K4M

• Superior Thickening Agent: Kima Chemical's HPMC K4M offers excellent thickening properties, making it ideal for use in construction materials, pharmaceuticals, and personal care products. These HPMC K4M properties ensure high-performance results, particularly in formulations that require controlled viscosity for optimal consistency.

• Enhanced Water Retention: The high water-retention capacity of HPMC K4M improves workability and durability in construction materials like cement-based mortars. Its unique HPMC K4M uses in preventing rapid drying and cracking contribute to the longevity and strength of the materials.

• Versatile Application: Kima Chemical’s HPMC K4M is compatible with a wide range of industries, including food, pharmaceuticals, and cosmetics. These diverse HPMC K4M uses make it a valuable multifunctional ingredient, serving as a binder, emulsifier, and film former.

• Eco-Friendly and Safe: HPMC K4M is non-toxic, biodegradable, and derived from natural cellulose. Available through wholesale HPMC options, it is an environmentally friendly choice for pharmaceutical applications, ensuring safety and regulatory compliance.