KIMA CHEMICAL CO.,LTD.
KIMA CHEMICAL CO.,LTD.
HPMC F4M

HPMC F4M

KimaCell®HPMC F4M Hydroxypropyl methylcellulose is used as a binder and disintegrant. Low-viscosity HPMC dissolves in water to form a clear to milky white viscous colloidal solution, which can be directly used as a binder. HPMC F4M can be used to improve the compressibility of drug particles.HPMC is a kind of non-ionic cellulose mixed ether. It is a semi-synthetic, inactive, viscoelastic polymer, often used as a lubricant in ophthalmology, or as an excipient in oral drugs.



Where to buy Cas 9004-65-3
HPMC F4M

Specification of HPMC F4M


HPMC F4M ( 9004 65 3 )

Hydroxypropyl Methyl Cellulose (HPMC)

Physical Analysis

Appearance

White to slightly off-white fibrous or granular powder.

Identification A to E

Conform

Solution appearance

Conform

Methoxy

27.0-30.0%

Hydroxypropoxy

4.0-7.5%

Loss on drying

5.0% Max

Residue on ignition

1.5% Max

pH

5.0-8.0

Apparent viscosity

3200-4800cps

Particle size

Min. 98% pass through 100 mesh

Heavy Metals

Heavy Metal

≤10ppm

Arsenic

≤3ppm

Lead

≤3ppm

Mercury

≤1ppm

Cadmium

≤1ppm

Micro bacteria

Total plate count

≤1000cfu/g

Yeast and Mould

≤100cfu/g

Coli form

Absent/g

Salmonella

Absent/g


Application of HPMC F4M


KimaCell® HPMC F4M is widely used in pharma industry.

  • Sustained-release agent: With 2-3 grams per day, the feeding amount of each 1-2G will show effect in 4-5 days.

  • Encapsulation: the encapsulation agent is made into an organic solvent solution or an aqueous solution for administration of tablets, especially for the prepared granules to be spray-encapsulated.

  • Eye drops: Since the osmotic pressure of methylcellulose aqueous solution is the same as that of tears, it is less irritating to the eyes, so it is added to eye drops as a lubricant for contacting the eyeball lens.

  • Jelly: as the base material of jelly-like external medicine or ointment.

  • Dipping medicine: as a thickener and water retention agent.



Advantages of HPMC F4M

  • Excellent Film-Forming Ability: HPMC F4M is renowned for its superior film-forming properties. This makes it an ideal ingredient in pharmaceuticals for coating tablets, providing a protective layer that controls the release of active ingredients, enhances the appearance of the tablet, and masks unpleasant tastes. In food applications, it helps create an appealing and protective coating on food items.

  • High Water Retention: HPMC F4M exhibits exceptional water retention capabilities, which is particularly beneficial in construction materials like cement and mortar. It improves workability, extends open time, and enhances adhesion. In the food industry, it helps maintain moisture in products, improving texture and shelf life, especially in baked goods and processed foods.

  • Thermal Gelation: One of the unique properties of HPMC F4M is its ability to undergo thermal gelation. When heated, it forms a gel, which reverts to a liquid state upon cooling. This reversible gelation property is advantageous in various applications, such as in the preparation of food gels, heat-resistant coatings, and controlled-release drug formulations.

  • Non-Ionic Nature: HPMC F4M is non-ionic, making it compatible with a wide range of substances without reacting with other ionic compounds. This property ensures its stability and effectiveness in diverse formulations, from pharmaceutical drugs to personal care products. Its non-ionic nature also reduces the risk of adverse reactions, making it safer for use in sensitive applications like ophthalmic solutions and skin care products.



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