KimaCell®HPMC E50 Hydroxypropylmethylcellulose is a multi-purpose non-ionic cellulose derivative, mainly used as a solid preparation disintegration and binder, because the powder of the HPMC E50 has a large surface area and porosity, it can quickly absorb water and swell, and is used in tablets At the same time, the tablet disintegrates quickly, and its rough structure has a large inlay between the drug and the particles, which can significantly increase the hardness of the tablet without affecting the disintegration, thereby accelerating the dissolution rate of the drug and improving the bioavailability. The dosage of this product is generally about 2-5%. In tablet production, HPMC E50 can be used for internal addition in wet granulation, or it can be added externally or both internally and externally for better effect.
HPMC E50 Hydroxypropyl Methyl Cellulose (HPMC) | |
Physical Analysis | |
Appearance | White to slightly off-white fibrous or granular powder. |
Identification A to E | Conform |
Solution appearance | Conform |
Methoxy | 28.0-30.0% |
Hydroxypropoxy | 7.0-12.0% |
Loss on drying | 5.0% Max |
Residue on ignition | 1.5% Max |
pH | 5.0-8.0 |
Apparent viscosity | 40-60cps |
Particle size | Min. 98% pass through 100 mesh |
Heavy Metals | |
Heavy Metal | ≤10ppm |
Arsenic | ≤3ppm |
Lead | ≤3ppm |
Mercury | ≤1ppm |
Cadmium | ≤1ppm |
Micro bacteria | |
Total plate count | ≤1000cfu/g |
Yeast and Mould | ≤100cfu/g |
Coli form | Absent/g |
Salmonella | Absent/g |
HPMC E50 (Hydroxypropyl Methylcellulose E50) is a type of cellulose ether, a chemically modified form of cellulose. It is produced by reacting natural cellulose with propylene oxide and methyl chloride, resulting in a white, odorless, and tasteless powder. This water-soluble polymer is characterized by its ability to form thick gels, improve solubility, and provide enhanced stability in various formulations. The "E50" in its name refers to its degree of substitution, which is typically around 50%, indicating the amount of hydroxypropyl and methyl groups introduced to the cellulose structure. Methocel E50 is known for its excellent dispersibility and controlled-release properties when dissolved in water. It is considered non-toxic, biodegradable, and environmentally friendly.
KimaCell® HPMC E50 is a chemically inert substance, compatible with most active drugs and preparation excipients. HPMC E50 has following advantages in pharmaceutical excipients:
Reduce the difficulty and time of prescription screening
Increase the success rate of R&D and accelerate the launch of products
Meet the sustained release requirements of various solubility active drugs
very narrow viscosity range
Ensure the stability of drug release
Reduce batch-to-batch variation
Strict particle size control - 75μm (200 mesh)
Uniform particle size is conducive to the application of powder direct compression process, which is conducive to rapid hydration and gel layer formation
Reduce shipping time
Guaranteed timely supply
Meet the requirements of USP/EP/JP
Reduce the number of prescriptions
Shorten development time
Market acceptability
Prescriptions can be considered GMO/TSE/BSE free
Kima Chemical is committed to delivering HPMC E50 with the highest standards of purity and performance. The company utilizes advanced production techniques and stringent quality control measures to ensure that every batch of Methocel E50 meets or exceeds international standards. This commitment to quality guarantees that customers receive a consistent, reliable product every time.
Kima understands that the viscosity and solubility of HPMC E50 are critical factors in many formulations. Kima's expertise in adjusting these properties ensures that the product can be customized to meet the specific requirements of a wide range of applications. Whether a customer needs a low-viscosity grade for easy processing or a higher-viscosity variant for thickening, Kima provides tailored solutions that optimize performance.
Methocel E50 from Kima Chemical complies with the most stringent industry regulations. The company holds ISO 9000 certifications, ensuring that its manufacturing processes meet global standards for quality and environmental management. These certifications provide customers with the confidence that Kima's products meet both regulatory requirements and international safety standards.
Kima offers HPMC E50 at competitive prices, allowing businesses to benefit from high-quality materials while maintaining cost efficiency. The company's large-scale production capabilities and efficient supply chain management help keep costs low, making it a cost-effective choice for customers who require reliable, premium-grade products without the premium price tag.