Hydroxypropyl Methyl Cellulose Phthalate (HPMC-P) Wholesale

Hydroxypropyl methyl cellulose phthalate (HPMCP) , also known as Hypromellose phthalate, is a type of cellulose derivative that is commonly used in pharmaceuticals as a coating agent for solid oral dosage forms such as tablets, capsules, and granules. It is a water-insoluble polymer that is derived from cellulose by esterification of the hydroxyl groups with methyl chloride and propylene oxide, followed by phthalic anhydride.

HPMCP is used as a pH-sensitive polymer, meaning that it is insoluble at low pH (e.g. in the acidic environment of the stomach) but becomes soluble at higher pH (e.g. in the more alkaline environment of the small intestine). This property makes HPMCP an effective enteric coating agent that can protect the drug from acidic degradation in the stomach and deliver it to the intestine, where it can be absorbed more effectively.

In addition to its enteric coating properties, HPMCP is also used as a matrix-forming agent and binder in sustained-release formulations. It has excellent film-forming properties, making it an effective coating agent for tablets, and it can be used to control the release of drugs from solid dosage forms.

HPMCP is an important polymer in pharmaceutical applications, especially in the development of solid oral dosage forms. Its pH-sensitive and film-forming properties make it an effective enteric coating agent and a versatile matrix-forming agent for sustained-release formulations.

Types of Hydroxypropyl Methyl Cellulose Phthalate (HPMC-P)

What's The Structure of Hydroxypropyl Methyl Cellulose Phthalate?

Hydroxypropyl methyl cellulose phthalate (HPMCP) is a complex polymer with a chemical structure that includes several repeating units. The structure of HPMCP is derived from the cellulose molecule, which is modified with the addition of methyl and hydroxypropyl groups, as well as phthalic acid groups.

The basic structure of HPMCP consists of a cellulose backbone with multiple methyl and hydroxypropyl groups attached to the hydroxyl (-OH) groups of the glucose units. These side chains alter the physical and chemical properties of the cellulose backbone, making it more soluble in certain solvents and more resistant to degradation.

In addition to the methyl and hydroxypropyl groups, HPMCP also contains phthalic acid groups that are esterified to the hydroxyl groups of the cellulose backbone. These phthalic acid groups provide HPMCP with its pH-sensitive properties, causing it to become soluble in alkaline environments and insoluble in acidic environments.

The specific structure of HPMCP can vary depending on the degree of substitution of the methyl and hydroxypropyl groups, as well as the degree of phthalation. The degree of substitution refers to the number of methyl and hydroxypropyl groups that are attached to the cellulose backbone, while the degree of phthalation refers to the number of phthalic acid groups that are esterified to the cellulose backbone. The degree of substitution and phthalation can be controlled during the synthesis of HPMCP, allowing for the production of polymers with varying physical and chemical properties.

What's The Structure of Hydroxypropyl Methyl Cellulose Phthalate

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